Balance of nature: necessary viruses like bacteriophages (Introduction)

by David Turell , Thursday, August 24, 2023, 17:21 (247 days ago) @ David Turell
edited by David Turell, Thursday, August 24, 2023, 17:36

Another review:

https://bigthink.com/life/phage-most-abundant-life-form-license-kill/?utm_campaign=week...

"Bacteriophages, known simply as “phages” for short, are viruses that infect and kill bacteria. Essentially harmless to humans, they exist solely to inject their genes into bacterial cells, where they can either lurk indefinitely or replicate madly.

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"For every type of cellular life on earth — bacterial, fungal, animal or plant, and the weird things somewhere in between — there are viruses that have evolved to infect them, and together these viruses outnumber all other living entities on Earth. While we commonly associate viruses with disease and death, just a tiny fraction are a danger to us. The vast majority are phages. And it is only very recently that we have begun to understand that phages are an essential part of the living fabric of the planet, drivers of innovation, diversification and change. (my bold)

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"Confusingly, bacteria and viruses are often grouped together simply as “germs,” but they are distinct in important ways. The most basic difference between them is that bacteria are cells and viruses are not. Cells are biology’s basic units of life — microscopic capsules with everything needed for life and replication contained within a fat-based membrane and, sometimes, a tough outer wall. All life on the planet — except viruses — consists of cells, either working in concert with one another (like the human body, for example, a network of trillions of related cells arranged to form tissues and organs) or existing just fine as single cells.

"Viruses, conversely, are far less complex. At their simplest, they are little more than a length of genetic material (normally DNA, deoxyribonucleic acid, but sometimes its chemical cousin, RNA, ribonucleic acid) wrapped in a protective protein capsule. Outside of a host, they are inert, lifeless even, lacking the biochemical components to do anything with the information contained in their genes.

"In order to replicate, the virus must get inside a cell. Viruses have been described as living “a kind of borrowed life,” only ever able to exert an influence on the world when inside a host cell. It’s a little like how a computer virus is just a piece of code on a USB stick — unable to do anything when lying in a drawer — until it is placed into a computer, when it can suddenly instruct that computer’s systems to send copies of itself to a thousand inboxes around the world. This reliance on other life is, in part, why there has always been a debate over whether viruses are “alive” or not. To me, the question is unhelpful, suggesting that viruses are somehow not a proper, paid-up member of our wonderful living world.

"Whether or not viruses meet the criteria we have decided characterizes a distinct living being, they are an essential biological component of the ecosystems that have developed on Earth. They are built from the same basic building blocks as life, use the same chemical language as life, evolve and replicate alongside life, and interact with and transform life. Some scientists believe that all life may have evolved from self-replicating entities more akin to viruses than cells. And by operating in the fascinating and illuminating grey area where complex chemistry becomes simple biology, they can arguably tell us more about what life is than living creatures so complex that they may never be fully understood.

"Bacteria are also essential to all life on Earth. Although we have “learnt to hate and fear them,” as the science writer Ed Yong puts it, just a hundred or so of the many thousands of species of bacteria in the world colonize our body in a way that makes us ill or causes disease. Even these mostly live quite happily on and around us without our noticing, only causing ill health when a vulnerability in our immune systems is exposed. The rest perform a suite of essential environmental services that make our planet hospitable. They capture chem­ical and solar energy to form the foundational layer of the food chains that support the rest of life on Earth; they take inorganic material, waste products, and dead things and re­cycle them back into forms that can be used by other life. They produce 20% of the atmospheric oxygen we breathe. They help us digest our food, help plants absorb nutrients, protect us from other microbes, and ferment some of our favorite foods. They have adapted and co-evolved to live in almost every environmental niche on the planet, from boiling vents at the bottom of the sea to the internal organs and tissues of other life, from lakes with the acidity of battery acid to the nodules in the roots of our most important crops. (my bold)

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"Researchers estimate there may be as many as 10^31 phages on Earth — that’s 10 with 30 zeros after it — a truly preposterous number that equates to around a trillion phages for every grain of sand on the planet."

Comment: Wow! Phages and bacteria are very mostly good. What a surprise for dour dhw.