human pregnancy strange progesterone activity (Introduction)

by David Turell , Tuesday, April 21, 2020, 21:58 (1457 days ago)

Our upright posture requires a different flatter broader shape to the pelvis than found in other primates. Our babies have bigger heads requiring larger pelvic openings, and the birth canal is tortuous, requiring a 90 degree turn and a 180 degree spin. In all other primates it is a direct shot. Squeeze hard and spit it out. Now it is found our progesterone levels and activities are very different:

https://medicalxpress.com/news/2020-04-human-pregnancy-weirdnew-mystery.html

"From an evolutionary perspective, human pregnancy is quite strange, says University at Buffalo biologist Vincent Lynch.

"'or example, we don't know why human women go into labor," Lynch says. "Human pregnancy tends to last longer than pregnancy in other mammals if you adjust for factors like body size. The actual process of labor tends to last longer than in other animals. And human pregnancy and labor are also much more dangerous."

"Past research has shown that the progesterone receptor gene underwent rapid evolution in humans, and some scientists have suggested that these swift changes occurred because they improved the function of the gene. This is called positive selection.

"But Lynch and Marinic's study—published online on April 17 in the journal PLOS Genetics—draws a different conclusion.

"Their research finds that while the progesterone receptor gene evolved rapidly in humans, there's no evidence to support the idea that this happened because those changes were advantageous. In fact, the evolutionary force of selection was so weak that the gene accumulated many harmful mutations as it evolved in humans, Lynch says. (my bold)

"The results come from an analysis of the DNA of 115 mammalian species. These included a variety of primates, ranging from modern humans and extinct Neanderthals to monkeys, lemurs and lorises, along with non-primate mammalian species such as elephants, pandas, leopards, hippos, aardvarks, manatees and walruses.

T"he findings were a surprise, Lynch says.

"'I thought that the progesterone receptor gene would have evolved to respond better to progesterone, to be better at suppressing inflammation or contractions to keep us pregnant for longer. It looks like it's the reverse: In human pregnancy, there's just an incredible amount of progesterone around, and yet the gene is less good at doing its job. I wonder if this might predispose us to things like preterm birth, which is not that common in other animals."

***

"During human pregnancy, these receptors detect the presence of progesterone, an anti-inflammatory hormone that pregnant women and the placenta produce at various points in time. When progesterone is present, the receptors jump into action, triggering processes that help keep women pregnant in part by preventing the uterus from contracting, reducing uterine inflammation, and suppressing the maternal immune response to the fetus, Lynch says.

"In addition to exploring the evolutionary history of the progesterone receptor gene, Lynch and Marinic conducted experiments to test whether mutations in the human version of the gene altered its function. The answer is yes.

"As the scientists wrote in their paper, "We resurrected ancestral forms of the progesterone receptor and tested their ability to regulate a target gene. We found that the human progesterone receptor forms have changed in function, suggesting the actions regulated by progesterone may also be different in humans. Our results suggest caution in attempting to apply findings from animal models to progesterone biology of humans.'"

Comment: Note my bold. We are very different. These Darwinists should accept that and accept the differences.