Tony: I think the researches stopped to early in their traceback. For example, what causes the decline in GnRH production. What are the triggers for that production? Is there another chemical or process that affects that production? Etc, etc.. 
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> Would be interesting to drill down to the root cause instead of looking at the end effects.-Having been involved in some research I think an answer to your comment is, you have to start somewhere, then work back to understand the underlying controls. I'll bet they do just that. A finding like this will justify new grants.