brain plasticity: astroglia modification (Introduction)

by David Turell , Friday, February 19, 2016, 15:38 (2991 days ago) @ David Turell

Astroglias modify neuronal function and neurons can modify astroglias all through life, not just at the start of life:-http://www.the-scientist.com/?articles.view/articleNo/45376/title/Adjustable-Brain-Cells/&utm_campaign=NEWSLETTER_TS_The-Scientist-Daily_2016&utm_source=hs_email&utm_medium=email&utm_content=26432384&_hsenc=p2ANqtz-_vYhx6wcIDvfBLPvQokVxVFE9vU8q9BN7fiLXQYESIVB_ywTfoM6TRixdKhUo99oCyq6SsWXp6pCIKQYYX6Upl6yJfvw&_hsmi=26432385/-"Neurons in the adult mouse brain can shape the features and physiologies of nearby astroglial cells, according to a study published today (February 18) in Science. Researchers at McGill University in Montreal and their colleagues have identified a molecular signal called sonic hedgehog (Shh), secreted by neurons, that acts as the agent of change.-***-"Astroglia are non-neuronal cells in the central nervous system that generally support and modulate neuronal function. The mammalian brain has an assortment of astrocytes, which perform a variety of specialized functions. This diversity was largely thought to be established during embryogenesis and early postnatal development, said Keith Murai of McGill who led the new research. “But after that,” he said, “the properties of these cells were thought to be solidified . . . for the rest of their lives.”-"Murai and his colleagues had a different view, however. “Some of these [astrocytes] are so specialized around certain neural circuits that it was hard to imagine that all of the properties of these cells could be determined by that point [in development],” he said. After all, the neural circuitry itself isn't fully formed until much later.
To investigate whether astrocyte identity might continue to be shaped beyond the perinatal period, Murai's team searched for gene products in adult neurons and astrocytes that might govern continuing development. To simplify matters, the researchers focused on the cerebellar cortex, where just two types of astrocyte exist—Bergmann glial cells (BGs), which encapsulate the impulse-receiving regions of Purkinji cell neurons (PCs), and velate astrocytes (VAs), which surround granule cell neurons (GCs). Their searches revealed many candidate factors, said Murai, but one pathway kept coming up: Shh signaling.-"Shh is a developmental morphogen known to have many important roles in the developing embryo, including the specification of cells in the brain, explained Murai. “People thought that the pathway was shut down and eliminated from the brain after it developed,” he said, “but as it turns out, this pathway is very potent even in the adult brain.”-***-"The team also found evidence that astrocytes in other brain regions were influenced by Shh manipulations, and that these cells' electrophysiologies were altered as a result.-“'The key message is that astrocytes' molecular fate is not hardwired,” said cell biologist Cagla Eroglu of Duke University in Durham, North Carolina, who did not participate in the study. The shapes of these cells appear to be less malleable, however. While Shh signaling influenced astrocyte expression profiles and electrical behaviors, the cells' morphologies remained largely unchanged."-Comment: Just more evidence of how dynamic is brain plasticity. By the way, astroglias are also referred as astrocytes, all part of the glial group of non-neuron cells in eh brain.