Immunity: gene controls through special proteins (Introduction)

by David Turell , Monday, October 15, 2018, 19:03 (2013 days ago) @ David Turell

Immunity is essential to fight infection for any living organism, since infective organisms are ubiquitous. It has complex controls:

https://medicalxpress.com/news/2018-10-immune-health-meticulously-dna.html

"The new study published today in Nature Immunology shows how Pax5 helps to efficiently organise the genetic information (DNA) required for our immune cells to maintain their form, function and help fight disease. The findings also suggest that a breakdown in this process of organisation by Pax5 could increase the risk of diseases such cancer.

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"Dr. Johanson said the researchers had shown, for the first time, that Pax5 could sweep across the genome and fold, twist and store DNA for B cells in a fantastically ordered way—making each cell into a jam-packed but very neat suitcase.

"'This immaculate organisation is crucial because each cell contains roughly two meters of DNA—that's a huge amount of material to fit inside something smaller than a grain of sand.

"'Every second of every day, different cells require access to highly specific parts of DNA in order to perform a myriad of jobs that help keep us healthy," he said.

"Dr. Johanson said life depended on cells accessing what they needed, when they needed it.
"For instance, immune B cells must access the right information to produce potentially life-saving antibodies that are critical for vaccine and immune responses.

"'Think of how a meticulously ordered suitcase increases your chance of finding a specific item of clothing at a moment's notice, and, how a jumbled case could work against you finding what you need. In the case of our bodies, the difference between order and disorder can be a matter of life and death," he said.

"'Seemingly small errors in the process of DNA organisation can turn out to be very serious drivers for disease.

"A lack of instructions required to function can put cells at risk of morphing or devolving into something they perhaps shouldn't be—like a cancer cell. It is therefore unsurprising that Pax5 is faulty in many childhood leukaemias."

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"Dr. Allan said the findings were particularly intriguing because for two decades Pax5 was known only as a 'transcription factor'.

"'Transcription factors help cells identify the instructions they need, but there was no evidence they could also play a part in the organisation and upkeep of this information, until now," he said."

Comment: This study shows how complex the controls are to manipulate DNA to produce the correct antibodies at the right time. The system is too complex for chance Darwinist evolution to have developed it. It also shows the intelligent automaticity built into the immune system, which requires exact information to be stored, found, and presented appropriately. Life runs on stored information. This article is an exact exposition of Shapiro's work showing how cells can manipulate DNA for necessary purposes. Cells do operate intelligently they because they follow intelligent instructions.