Biological complexity: mitochondrial transport control (Introduction)

by David Turell , Thursday, September 15, 2022, 19:23 (590 days ago) @ David Turell

Across its double membrane:

https://www.sciencedaily.com/releases/2022/09/220915104719.htm

"Mitochondria, often referred to as the powerhouses of the cell, are bounded by a double membrane. The inner of the two membranes hosts a series of proteins that transfer electrons along what is called the electron transport chain. This electron transport is a crucial part of the processes that extract chemical energy from nutrients and ultimately store it in energy-rich molecules of adenosine triphosphate (ATP).

"The new insight from the Duke-NUS team reveals that small microproteins (also called peptides) play a previously unrecognised role in allowing the electron transport chain to form. Specifically, they appear to work together to assist and control the assembly of one of the central proteins of the chain, called Complex III. This role allows the microproteins to participate in regulating the levels of electron transport chain proteins, and therefore energy supply, in response to changes in energy demand.

"'Microproteins have fascinated but also mystified biologists from diverse fields for a long time," said Mr Liang Chao, co-first author of the study, who is a PhD candidate at Duke-NUS. "Our study provides an example of what they can do and how they participate in controlling energy metabolism at the deepest level of molecular detail."

"'Mitochondria are the batteries and factories of our cells, making not only energy but also many of the building blocks required for cells to multiply and stay alive," said Dr Shan Zhang, formerly a research fellow with Asst Prof Ho's Endogenous Peptides Lab, under Duke-NUS' CVMD Programme, and now an Assistant Professor at Zhejiang University, China. "We clearly see that modulating the levels of these microproteins can lead to or protect against mitochondrial dysfunction, which is a feature that underlies almost all types of common diseases.'"

Comment: What is not noted is mitochondria are controlled by their own DNA which is maternally sourced. This intricate system must have been designed.