Biological complexity: finding working proteins (Introduction)

by David Turell , Sunday, October 25, 2015, 22:36 (3098 days ago) @ David Turell

Working proteins are composed of two requirements, a special sequence of amino acids which will be several hundred acids long. Second, a required folding pattern which then produces the function of the single molecule. New research is trying to understand the mysteries of this process:-http://www.sciencedaily.com/releases/2015/10/151023121845.htm-"'We developed a model in which the amino acids that have a strong co-evolutionary relationship attracted each other, without further additional data," says Simone Marsili, researcher who has also participated in the project. "First, we simulate the folding process and then we can see how the simulations were able to predict the changes in shape of the proteins at different levels of complexity, including those required for kinases to function [these are key proteins in metabolic and cell signalling processes as well as in cell transport, amongst others]."-"This new computational method easily integrates experimental and genomic data through the use of the latest sequence analysis and 3D modelling technology. In addition, it demonstrates that genomic data can be a source of useful information to supplement the current tools used to study the structure and dynamics of proteins.-"'The ability to predict key features of proteins at this level of complexity will help to understand how the sequence of a protein determines its dynamics and, therefore, its functions," concludes Valencia." -Comment: the special sequence of amino acids will lead the the proper folding is the basic premise of this study. When first inventing life, imagine the problem of finding the right proteins for the functions needed, when it is unknown from the beginning which folds will work and which won't. This is why design has such strong support among those who look at the problem from this perspective. Since DNA makes proteins it is logical that DNA contains the information to make the correct proteins. Big question how did that initial information develop? All protein molecules are large so the odds of finding picking the right ones from scratch are tiny and each single cell is made of thousands of different molecules. No wonder Paul Davies refers to life as the "fifth miracle'. this article will show my point mathematically:-http://www.darwinismrefuted.com/molecular_biology_03.html-"For instance, an average-sized protein molecule composed of 288 amino acids, and contains twelve different types of amino acids can be arranged in 10300 different ways. (This is an astronomically huge number, consisting of 1 followed by 300 zeros.) Of all of these possible sequences, only one forms the desired protein molecule. The rest of them are amino-acid chains that are either totally useless, or else potentially harmful to living things. -"In other words, the probability of the formation of only one protein molecule is "1 in 10^300. "The probability of this "1" actually occurring is practically nil. (In practice, probabilities smaller than 1 over 10^50 are thought of as "zero probability")." (The bound for improbability is also to be 1 over 10^150)