Biological complexity: feast or famine cell controls (Introduction)

by David Turell , Wednesday, November 06, 2019, 00:09 (1634 days ago) @ David Turell

A special epigenetic mark on histones controls cells' use of energy supplies:

https://phys.org/news/2019-11-feast-famine-scientists-key-bio.html

"The scientists, in a study published in Molecular Cell, found that a chemical mark on histones—a key protein involved in the function of our DNA—occurs naturally under nutrient-limited conditions as cells change the way they make energy, and serves to repress genes that would otherwise drive cell growth. The chemical mark is called crotonylation, and until now its function has not been well understood.

"'Our findings help explain how a changing nutrient environment outside the cell is able to communicate to the nucleus of the cell in such a way that the appropriate genes are switched on or off," said study co-senior author Brian Strahl,

***

"'We identified mechanisms by which cells can quickly reduce their energy consumption as soon as it becomes limited in the local environment. Expression of growth genes are extremely energy-demanding, and they need to be tightly regulated in nutrient-limited environments in order to ensure survival."

"The finding advances basic science by revealing a key mechanism through which cells alter gene expression programs in order to adapt to low-nutrient conditions

"Crotonyl marks occur on the support proteins called histone proteins around which DNA normally is spooled. Like other chemical marks on histones, crotonyl marks are thought to work by loosening or tightening the local wrapping of DNA so that affected genes can become active or are forced into inactivity. Such histone marks are broadly known as "epigenetic" marks because they effectively help control, or program, which genes are turned on and which are turned off in a cell.

"The precise functions of crotonyl marks have been somewhat mysterious. But Strahl and Morrison's labs found evidence that these marks occur naturally under low-nutrient conditions when the main form of chemical energy in cells, related to glucose, is less available and cells start to scavenge chemical energy from fat-related molecules. Fatty acids are generated as byproducts of this alternate energy production process and soon make their way to the nucleus. There enzymes start attaching one form of these fatty acids, crotonyls, to histones. That forces a change in gene activity that slows growth and otherwise adapts the cell for low-nutrient conditions.

"'It's an elegant way that nature has evolved to control the genome using metabolic events happening in the cell," Strahl said.

"Crotonylation in this context appears to have nearly the opposite function of a better-known histone marking called acetylation, which uses byproducts of normal, glucose-related energy production to keep growth genes switched on."

Comment: For decades medicine has known that human starvation results in the basal metabolism reduced by as much as 300 calories a day to preserve survival for as long as possible. This mechanism has now been found in specialized protein markers, which chance evolution could not have found. This is designed.